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Image Search Results
Journal: bioRxiv
Article Title: Angiotensin II Type 2 Receptor Potentiates Skeletal Muscle Satellite Cell Differentiation via the GSK3β/β-catenin Pathway
doi: 10.1101/2022.09.30.510328
Figure Lengend Snippet: (A) Phosphoprotein changes analyzed by PhosphoExplorer array in muscle satellite cells (SCs) transfected with AT2R or control siRNA, followed by induction of differentiation for 2 days. Log2 fold change values of AT2R siRNA-transfected cells compared to control are shown, with increased phosphorylation in red and decreased phosphorylation in blue. (B, C) IPA Canonical Pathway analysis (B) and Diseases and Functions Annotations (C) for the phosphoprotein changes with absolute log2 fold change values over 1 (i.e. >2 fold change). Bars indicate -log 10 p-value, and lines show the ratio of the proteins that were changed among the proteins associated with each pathway. The red and blue colors of the bar chart indicate activation z-score, and only the pathways with absolute z-scores higher than 2 (i.e. considered statistically significant). (D) Changes in phosphorylation levels in GSK3β (Ser216 and Ser9), and β-catenin (Tyr654, Thr41/Ser45, Ser37, Ser33 and Tyr489).
Article Snippet: The
Techniques: Transfection, Activation Assay